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6-APB (6-(2-aminopropyl)benzofuran) is a substituted benzofuran and substituted phenethylamine empathogenic psychoactive chemical. In press headlines, 6-APB and related compounds are alternatively referred to as “Benzofury.” The 3,4-methylenedioxyphenyl ring system has been substituted with a benzofuran ring, making it structurally similar to MDA. If you want to buy 6-APB online, PurelyChem is the best place for you. We have got 6-APB for sale at the best rates here. Order today!
Pharmacokinetics of 6-APB
Although the pharmacokinetics of 6-APB has not been examined, user reports can provide some insight. These data point to a 40–120-minute onset time. The drug’s peak effects last 7 hours, followed by a 2-hour comedown phase and up to 24 hours of after-effects.
Pharmacodynamics of 6-APB
6-APB is a serotonin-norepinephrine–dopamine reuptake inhibitor (SNDRI) that inhibits the norepinephrine transporter (NET), dopamine transporter (DAT), and serotonin transporter (SERT) with Ki values of 117, 150, and 2698 nM, respectively. Furthermore, 6-APB is both a reuptake inhibitor and a release agent for these monoamine neurotransmitters; that is, it is a serotonin-norepinephrine-dopamine releasing agent.
6-APB is a powerful full agonist of the serotonin 5-HT2B receptor, with a higher affinity for this target than any other site, in addition to actions at monoamine transporters. In addition, unlike MDMA, 6-APB has a 100-fold preferential affinity for the 5-HT2B receptor over the 5-HT2A and 5-HT2C receptors. It is significantly more potent and selective as a 5-HT2B receptor agonist than the standard 5-HT2B receptor agonist, BW-723C86, which is routinely utilized in 5-HT2B receptor studies.
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